4-Morpholinecarbonyl chloride → 1-(Morpholine-4-carbonyl)indoline-5-sulfonamide

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 55, indoline-5-sulfonamide (Intermediate 54A, 250 mg, 1.26 mmol) and morpholine-4-carbonyl chloride (206 μL, 1.77 mmol) were converted to the title compound (230 mg, 59%) after purification using preparative HPLC. 1H NMR (DMSO-d6) δ 7.61-7.58 (m, 2H), 7.15-7.12 (m, 3H), 3.92 (t, J=6.5 Hz, 2H), 3.78-3.75 (m, 2H), 3.66-3.63 (m, 4H), 3.10-3.07 (m, 4H); MS(ESI+) m/z 312.2 (M+H)+.

Provenance & Evidence