1-(2-chloroacetyl)-2,3-dihydro-1H-indole-5-sulfonamide → 1-(2-Chloroethyl)indoline-5-sulfonamide

HRID 528842노트

반응식

HRID 528842 반응식
C(N1C2C(=CC(S(N)(=O)=O)=CC=2)CC1)C.[Cl:16][CH2:17][C:18]([N:20]1[C:28]2[C:23](=[CH:24][C:25]([S:29]([NH2:32])(=[O:31])=[O:30])=[CH:26][CH:27]=2)[CH2:22][CH2:21]1)=O>>[Cl:16][CH2:17][CH2:18][N:20]1[C:28]2[C:23](=[CH:24][C:25]([S:29]([NH2:32])(=[O:30])=[O:31])=[CH:26][CH:27]=2)[CH2:22][CH2:21]1

참가 물질

3

반응물 2

HCID 162270611-(2-chloroacetyl)-2,3-dihydro-1H-indole-5-sulfonamide2회HCID 321037261-ethyl-2,3-dihydro-1H-indole-5-sulfonamide

생성물 1

HCID 867188861-(2-Chloroethyl)indoline-5-sulfonamide수율 79%

실험 절차

Following a procedure analogous to that for the synthesis of Intermediate 53, 1-(2-chloroacetyl)indoline-5-sulfonamide (Intermediate 75A, 400 mg, 1.46 mmol) was converted to the title compound (300 mg, 79%). 1H NMR (DMSO-d6) δ 7.45 (dd, J=8.3, 1.9 Hz, 1H), 7.41 (br s, 1H), 6.91 (s, 2H), 6.56 (d, J=8.4 Hz, 1H), 3.83-3.80 (m, 2H), 3.60-3.51 (m, 4H), 2.99 (t, J=8.7 Hz, 2H); MS(ESI+) m/z 261.2 (M+H)+.

출처 및 근거

ORD 기록
ord-301ae998e06e4360853ed54db6a04660
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09346795B2

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