Dichloromethane → HCID 86718895, compound

Participants

Reaction Steps

To a solution of (S)-tert-butyl 3-((dimethylamino)methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (Edwards, P. J., European Patent Application No. 1598341 (2005)) (66 mg, 0.23 mmol) in CH2Cl2 (2.3 mL) was added TFA (1.4 mL, 18.1 mmol). After stirring for 3 h at room temperature, the reaction mixture was concentrated in vacuo. Next, HCl (1N solution in Et2O) was added and the mixture was concentrated in vacuo (3×) to give a crude oil which was used without purification in the preparation of Example 108. MS(ESI+) m/z 790.2 (M+H)+.

Provenance & Evidence