Piperidin-4-ol → (S)-1-((1,2,3,4-Tetrahydroisoquinolin-3-yl)methyl)piperidin-4-ol

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Example 107, (S)-tert-butyl 3-formyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (57 mg, 0.22 mmol) and piperidin-4-ol (26 mg, 0.26 mmol) provided a crude oil which was used without purification in the preparation of Example 110. MS(ESI+) m/z 247.2 (M+H)+.

Provenance & Evidence