1-Methylpiperazine → (S)-3-((4-Methylpiperazin-1-yl)methyl)-1,2,3,4-tetrahydroisoquinoline

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Example 107, (S)-tert-butyl 3-formyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (57 mg, 0.22 mmol) and 1-methylpiperazine (26 mg, 0.26 mmol) provided a crude oil which was used without purification in the preparation of Example 112. MS(ESI+) m/z 246.1 (M+H)+.

Provenance & Evidence