Butanal → HCID 28447315, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 137, 3,4-dimethoxyaniline (500 mg, 3.26 mmol) and butyraldehyde (290 μL, 3.26 mmol) were converted to the title compound (600 mg, 83%). 1H NMR (CDCl3) δ 6.81-6.70 (m, 1H), 6.27-6.21 (m, 1H), 6.16 (dd, J=8.5, 2.5 Hz, 1H), 3.85 (s, 3H), 3.81 (s, 3H), 3.08 (t, J=7.0 Hz, 2H), 1.56-1.40 (m, 4H), 0.99-0.93 (m, 3H); MS(ESI+) m/z 210.2 (M+H)+.

Provenance & Evidence