Butanal → N-butyl-4-methoxyaniline

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 137, 4-methoxyaniline (500 mg, 4.06 mmol) and butyraldehyde (360 μL, 4.06 mmol) were converted to the title compound (700 mg, 88%). 1H NMR (CDCl3) δ 6.89-6.73 (m, 2H), 6.69-6.50 (m, 2H), 3.76 (s, 3H), 3.10 (t, J=7.2 Hz, 2H), 1.70-1.28 (m, 4H), 1.02-0.90 (m, 3H); MS(ESI+) m/z 180.1 (M+H)+.

Provenance & Evidence