Butanal → HCID 15482224, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 137, 1,4-benzodioxan-6-amine (410 μL, 3.31 mmol) and butyraldehyde (300 μL, 3.31 mmol) were converted to the title compound (620 mg, 83%). 1H NMR (CDCl3) δ 6.77-6.58 (m, 1H), 6.28-5.96 (m, 2H), 4.30-4.12 (m, 4H), 3.04 (t, J=7.2 Hz, 2H), 1.65-1.49 (m, 2H), 1.49-1.37 (m, 2H), 0.95 (t, J=7.4 Hz, 3H); MS(ESI+) m/z 208.3 (M+H)+.

Provenance & Evidence