Butanal → HCID 71086468, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 137, 3′-chlorobiphenyl-3-amine (Oakwood, 15 mg, 0.074 mmol) and butyraldehyde (7 μL, 0.074 mmol) were converted to a crude oil which was used without purification in the preparation of Example 143. 1H NMR (CDCl3) δ 8.17 (d, J=0.9 Hz, 1H), 7.86-7.42 (m, 3H), 7.41-7.07 (m, 3H), 6.78-6.57 (m, 1H), 3.00-2.87 (m, 2H), 1.63-1.46 (m, 2H), 1.47-1.34 (m, 2H), 1.02 (t, J=7.4 Hz, 3H); MS(ESI+) m/z 260.2 (M+H)+.

Provenance & Evidence