Butanal → HCID 58942896, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 137, ethyl 2-(4-aminophenyl)acetate (500 mg, 2.79 mmol) and butyraldehyde (250 μL, 2.79 mmol) were converted to the title compound (600 mg, 87%). 1H NMR (CDCl3) δ 7.12-7.04 (m, 2H), 6.60-6.52 (m, 2H), 4.14 (q, J=7.0 Hz, 2H), 3.49 (s, 2H), 3.11 (t, J=7.0 Hz, 2H), 1.66-1.50 (m, 2H), 1.50-1.36 (m, 2H), 1.25 (t, J=7.0 Hz, 3H), 0.96 (t, J=7.3 Hz, 3H); MS(ESI+) m/z 236.3 (M+H)+.

Provenance & Evidence