Reaction Steps
Following a procedure analogous to that for the synthesis of Intermediate 91F, methyl 4-(N-butyl-4-chloro-5-methyl-1-(4-(naphthalen-2-ylsulfonylcarbamoyl)-2-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-1H-pyrazole-3-carboxamido)benzoate (Example 154, 2 mg, 2.0 μmol) was converted to the title compound (2 mg, 94%). 1H NMR (CD3OD, 2:1 mixture of amide rotamers) δ 8.71 (s, 1H), 8.10 (d, J=8.1 Hz, 1H), 8.06 (s, 2H), 8.04-7.97 (m, 2.5H), 7.93 (d, J=2.0 Hz, 0.5H), 7.87 (d, J=8.6 Hz, 1H), 7.75-7.64 (m, 3H), 7.54 (d, J=8.1 Hz, 0.5H), 7.41 (d, J=8.8 Hz, 0.5H), 7.22-7.18 (m, 3.5H), 7.01-6.99 (m, 1.5H), 6.73 (d, J=7.0 Hz, 1H), 4.97 (br s, 1H), 4.69 (br s, 1H), 4.52-4.31 (m, 2H), 4.17 (br s, 1H), 3.93 (br s, 1H), 3.64-3.43 (m, 1H), 2.94-2.78 (m, 1H), 2.21-2.17 (m, 1H), 2.16 (s, 2H), 2.14 (s, 1H), 2.06-2.00 (m, 1H), 1.64-1.56 (m, 1H), 1.44-1.20 (m, 3H), 0.93-0.81 (m, 3H); MS(ESI+) m/z 804.3 (M+H)+.
