HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Chloro-3-(dibutylcarbamoyl)-5-methyl-1H-pyrazol-1-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoic acid → 4-(4-Chloro-3-(dibutylcarbamoyl)-1H-pyrazol-1-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Chloro-3-(dibutylcarbamoyl)-5-methyl-1H-pyrazol-1-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoic acid | HCID 71062194 | — |
| Reactant | Ethyl 4-(4-chloro-3-(dibutylcarbamoyl)-1H-pyrazol-1-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate | HCID 71062365 | — |
| Product | 4-(4-Chloro-3-(dibutylcarbamoyl)-1H-pyrazol-1-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoic acid | HCID 71062569 | 94% |
Reaction Steps
Following a procedure analogous to that for the synthesis of Intermediate 1F, ethyl 4-(4-chloro-3-(dibutylcarbamoyl)-1H-pyrazol-1-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (155 mg, 0.27 mmol) was converted to the title compound (138 mg, 94%). MS(ESI+) m/z 537.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346795B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-a6200788798e4013ad651688c274df6e |
| Source note | uspto-grants-2016_05 |