HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-dibutyl-4-chloro-5-methyl-1H-pyrazole-3-carboxamide → N,N-Dibutyl-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-dibutyl-4-chloro-5-methyl-1H-pyrazole-3-carboxamide | HCID 71062189 | — |
| Reactant | Ethyl 5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole-3-carboxylate | HCID 71062309 | — |
| Product | N,N-Dibutyl-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole-3-carboxamide | HCID 71062468 | 83% |
Reaction Steps
Following a procedure analogous to that for the synthesis of Intermediate 1B, ethyl 5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole-3-carboxylate (2.15 g, 8.01 mmol) was converted to the title compound (2.35 g, 83%). MS(ESI+) m/z 352.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346795B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-283cc6188a734fbb81716f84ca8a64f2 |
| Source note | uspto-grants-2016_05 |