2-(4-Chloro-3-(dibutylcarbamoyl)-5-methyl-1H-pyrazol-1-yl)-5-(naphthalen-2-ylsulfonylcarbamoyl)benzoic acid → HCID 71062203, compound

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Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 91F, ethyl 2-(4-chloro-3-(dibutylcarbamoyl)-5-methyl-1H-pyrazol-1-yl)-5-(1-(3,4-dichlorobenzyl)indolin-5-ylsulfonylcarbamoyl)benzoate (355 mg, 0.44 mmol) was converted to the title compound (290 mg, 85%). 1H NMR (DMSO-d6) δ 8.14 (d, J=2.0 Hz, 1H), 8.17 (dd, J=8.3, 2.1 Hz, 1H), 7.69-7.57 (m, 5H), 7.32-7.30 (m, 1H), 6.65 (d, J=8.6 Hz, 1H), 4.45 (s, 2H), 3.53 (t, J=8.7 Hz, 2H), 3.40-3.28 (m, 4H), 3.05 (t, J=8.4 Hz, 2H), 2.11 (s, 3H), 1.56-1.41 (m, 4H), 1.33-1.27 (m, 2H), 1.15-1.08 (m, 2H), 0.91 (t, J=7.3 Hz, 3H), 0.74 (t, J=7.4 Hz, 3H); MS(ESI+) m/z 776.2 (M+H)+.

Provenance & Evidence