2-(4-Chloro-3-(dibutylcarbamoyl)-5-methyl-1H-pyrazol-1-yl)-5-(naphthalen-2-ylsulfonylcarbamoyl)benzoic acid → HCID 71062164, compound

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Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 91F, ethyl 2-(4-chloro-3-(dibutylcarbamoyl)-5-methyl-1H-pyrazol-1-yl)-5-(1-ethylindolin-5-ylsulfonylcarbamoyl)benzoate (180 mg, 0.27 mmol) was converted to the title compound (58 mg, 32%) after purification by preparative HPLC. 1H NMR (DMSO-d6) δ 8.41 (d, J=2.0 Hz, 1H), 8.17 (dd, J=8.3, 2.1 Hz, 1H), 7.69-7.64 (m, 2H), 7.52 (d, J=1.8 Hz, 1H), 6.83 (d, J=8.6 Hz, 1H), 3.54 (t, J=8.6 Hz, 2H), 3.28-3.24 (m, 6H), 3.00 (t, J=8.6 Hz, 2H), 2.10 (s, 3H), 1.57-1.41 (m, 4H), 1.33-1.26 (m, 2H), 1.14-1.08 (m, 5H), 0.91 (t, J=7.4 Hz, 3H), 0.75 (t, J=7.3 Hz, 3H); MS(ESI+) m/z 644.3 (M+H)+.

Provenance & Evidence