反应详情

Following a procedure analogous to that for the synthesis Example 106, 5-methyl-1H-pyrazol-3-amine (Aldrich, 486 mg, 5.00 mmol) and butyraldehyde (541 mg, 7.50 mmol) were converted to the title compound (555 mg, 53%). 1H NMR (CDCl3) δ 5.34 (s, 1H), 3.17 (t, J=7.3 Hz, 4H), 2.21 (s, 3H), 1.55 (td, J=15.1, 7.5 Hz, 4H), 1.34 (qd, J=15.0, 7.3 Hz, 4H), 0.94 (t, J=7.4 Hz, 6H); MS(ESI+) m/z 210.1 (M+H)+.