HCID 13721206, compound → HCID 71062589, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 224E, (E)-ethyl 2-(2-phenylhydrazono)acetate (22 mg, 0.11 mmol) and tert-butyl 4-(2-nitroprop-1-enyl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (48 mg, 0.11 mmol) were converted to the title compound (42 mg, 65%) as a colorless oil. 1H NMR (CDCl3, 1:1 mixture of amide rotamers) δ 8.10 (dd, J=8, 2 Hz, 1H), 8.06-8.04 (m, 1H), 7.49-7.40 (m, 6H), 7.21-6.81 (m, 4H), 5.02-4.96 (m, 1H), 4.49-4.28 (m, 3H), 4.17-4.03 (m, 1H), 3.54-3.33 (m, 1H), 2.82-2.43 (m, 2H), 2.19 (s, 3H), 1.61 (s, 9H), 1.28 (t, J=8 Hz, 1.5H), 1.23 (t, J=8 Hz, 1.5H); MS(ESI+) m/z 566.3 (M+H)+.

Provenance & Evidence