HCID 71060717, compound → HCID 71062366, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 223E, (E)-ethyl 2-(2-(4-phenoxyphenyl)hydrazono)acetate (55 mg, 0.19 mmol) and tert-butyl 4-(2-nitrohex-1-enyl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (90 mg, 0.19 mmol) were converted to the title compound (68 mg, 50%) as a pale yellow oil. 1H NMR (CDCl3, 1:1 mixture of amide rotamers) δ 8.09 (dd, J=8, 2 Hz, 1H), 8.05-8.03 (m, 1H), 7.44-6.82 (m, 14H), 5.02-4.98 (m, 1H), 4.48-4.39 (m, 1H), 4.34-4.27 (m, 2H), 4.14-3.98 (m, 1H), 3.58-3.35 (m, 1H), 2.83-2.50 (m, 4H), 1.61 (s, 9H), 1.27 (t, J=8 Hz, 1.5H), 1.23 (t, J=8 Hz, 1.5H), 1.16-0.89 (m, 4H), 0.65-0.60 (m, 3H); MS(ESI+) m/z 700.3 (M+H)+.

Provenance & Evidence