HCID 71060717, compound → HCID 71062333, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 223E, (E)-ethyl 2-(2-(4-(2-hydroxyethyl)phenyl)hydrazono)acetate (61 mg, 0.26 mmol) and tert-butyl 4-(2-nitrohex-1-enyl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (120 mg, 0.26 mmol) were converted to the title compound (29 mg, 17%) as a pale yellow oil. 1H NMR (CDCl3, 1:1 mixture of amide rotamers) δ 8.10 (dd, J=8, 2 Hz, 1H), 8.05-8.03 (m, 1H), 7.44-6.82 (m, 9H), 5.02-4.98 (m, 1H), 4.48-4.38 (m, 1H), 4.32-4.26 (m, 2H), 4.15-3.98 (m, 1H), 3.89-3.88 (m, 2H), 3.58-3.38 (m, 1H), 2.96-2.92 (m, 2H), 2.88-2.50 (m, 4H), 1.61 (s, 9H), 1.29 (t, J=8 Hz, 1.5H), 1.21 (t, J=8 Hz, 1.5H), 1.13-0.95 (m, 4H), 0.62-0.57 (m, 3H); MS(ESI+) m/z 652.3 (M+H)+.

Provenance & Evidence