HCID 71060717, compound → HCID 71062298, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 223E, (E)-ethyl 2-(2-(biphenyl-4-yl)hydrazono)acetate (35 mg, 0.13 mmol) and tert-butyl 4-(2-nitrohex-1-enyl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (60 mg, 0.13 mmol) were converted to the title compound (55 mg, 62%) as a pale yellow solid. 1H NMR (CDCl3, 1:1 mixture of amide rotamers) δ 8.13 (dd, J=8, 2 Hz, 1H), 8.09-8.07 (m, 1H), 7.74-7.43 (m, 10H), 7.23-6.86 (m, 4H), 5.02-4.98 (m, 1H), 4.55-4.47 (m, 1H), 4.37-4.31 (m, 2H), 4.20-4.02 (m, 1H), 3.58-3.35 (m, 1H), 2.90-2.51 (m, 4H), 1.61 (s, 9H), 1.32 (t, J=8 Hz, 1.5H), 1.26 (t, J=8 Hz, 1.5H), 1.21-0.97 (m, 4H), 0.66-0.62 (m, 3H); MS (ESI+) m/z 684.4 (M+H)+.

Provenance & Evidence