HRID529003

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12440775

3-Bromo-N,N-dimethylpropan-1-amine

C5H12BrN

结构：CCCCN(CCCC)C(=O)c1c[nH]c(-c2ccc(C(=O)OC)cc2C(=O)N2CCc3ccccc3C2)n1

HCID178449064

未命名化合物

PRODUCTS

生成物

结构：CCCCN(CCCC)C(=O)c1cn(CCCN(C)C)c(-c2ccc(C(=O)OC)cc2C(=O)N2CCc3ccccc3C2)n1

HCID71062235

未命名化合物

收率 78.7%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Intermediate 266A, methyl 4-(4-(dibutylcarbamoyl)-1H-imidazol-2-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (200 mg, 0.38 mmol) and 3-bromo-N,N-dimethylpropan-1-amine (77 mg, 0.46 mmol) were converted to the title compound (180 mg, 78%). MS(ESI+) m/z 602.6 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bf4a775bf2c24e618495888338b98fc2
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09346795B2
来源说明: uspto-grants-2016_05

反应 SMILES

[CH2:1]([N:5]([CH2:35][CH2:36][CH2:37][CH3:38])[C:6]([C:8]1[N:9]=[C:10]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][C:14]=2[C:23]([N:25]2[CH2:34][CH2:33][C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH2:26]2)=[O:24])[NH:11][CH:12]=1)=[O:7])[CH2:2][CH2:3][CH3:4].Br[CH2:40][CH2:41][CH2:42][N:43]([CH3:45])[CH3:44]>>[CH2:35]([N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:6]([C:8]1[N:9]=[C:10]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][C:14]=2[C:23]([N:25]2[CH2:34][CH2:33][C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH2:26]2)=[O:24])[N:11]([CH2:40][CH2:41][CH2:42][N:43]([CH3:45])[CH3:44])[CH:12]=1)=[O:7])[CH2:36][CH2:37][CH3:38]