1-Methylpiperazine → HCID 71062179, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-benzyl 1-methyl 4-(1-(2-chloroethyl)-4-(dibutylcarbamoyl)-1H-imidazol-2-yl)isophthalate (120 mg, 0.21 mmol) in dry DMF (2 mL) was added diisopropylethyl amine (26.5 mg, 0.21 mmol) and 1-methylpiperazine (21 mg, 0.21 mmol at room temperature. The reaction mixture was heated at 90° C. for 16 h, diluted with water and extracted with MTBE (3×). The combined organic layer was dried over Na2SO4 and concentrated in vacuo to give the crude product. The crude material was purified by flash chromatography (gradient from 0 to 5% MeOH/CH2Cl2) to provide the title compound (60 mg, 45%). MS(ESI+) m/z 619.2 (M+H)+

Provenance & Evidence