Methyl iodide → HCID 71062254, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 271F, 3-benzyl 1-methyl 4-(4-(dibutylcarbamoyl)-1H-imidazol-2-yl)isophthalate (370 mg, 0.75 mmol) and methyl iodide (106 mg, 0.75 mmol) were converted to the title compound (260 mg, 68%). 1H NMR (CDCl3) δ 8.70 (d, J=1.2 Hz, 1H), 8.24 (dd, J=8.0, 1.6 Hz, 1H), 7.52 (d, J=7.6 Hz, 1H), 7.43 (s, 1H), 7.37-7.33 (m, 3H), 7.28-7.27 (m, 2H), 5.17 (s, 2H), 3.98 (s, 3H), 3.92 (br s, 2H), 3.45 (br s, 2H), 3.24 (s, 3H), 1.68-1.52 (m, 4H), 1.37-1.24 (m, 4H), 0.94-0.90 (m, 6H); MS(ESI+) m/z 507.0 (M+H)+

Provenance & Evidence