HRID529027

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCN(CCCC)C(=O)c1cn(C)c(-c2ccc(C(=O)OC)cc2C(=O)O)n1

HCID71062205

未命名化合物

HCID86718892

未命名化合物

PRODUCTS

生成物

结构：CCCCN(CCCC)C(=O)c1cn(C)c(-c2ccc(C(=O)OC)cc2C(=O)N2Cc3ccccc3C[C@H]2CN=[N+]=[N-])n1

HCID71086334

未命名化合物

收率 91%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Intermediate 271H, 2-(4-(dibutylcarbamoyl)-1-methyl-1H-imidazol-2-yl)-5-(methoxycarbonyl)benzoic acid (230 mg, 0.55 mmol) and (S)-3-(azidomethyl)-1,2,3,4-tetrahydroisoquinoline (135 mg, 0.72 mmol) were converted to the title compound (280 mg, 91%). MS(ESI+) m/z 586.2 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e02a16481d3449639edac6ef56225db2
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09346795B2
来源说明: uspto-grants-2016_05

反应 SMILES

[CH2:1]([N:5]([CH2:27][CH2:28][CH2:29][CH3:30])[C:6]([C:8]1[N:9]=[C:10]([C:14]2[CH:22]=[CH:21][C:20]([C:23]([O:25][CH3:26])=[O:24])=[CH:19][C:15]=2[C:16](O)=[O:17])[N:11]([CH3:13])[CH:12]=1)=[O:7])[CH2:2][CH2:3][CH3:4].[N:31]([CH2:34][C@@H:35]1[CH2:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37][NH:36]1)=[N+:32]=[N-:33]>>[N:31]([CH2:34][C@@H:35]1[CH2:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37][N:36]1[C:16]([C:15]1[CH:19]=[C:20]([CH:21]=[CH:22][C:14]=1[C:10]1[N:11]([CH3:13])[CH:12]=[C:8]([C:6](=[O:7])[N:5]([CH2:27][CH2:28][CH2:29][CH3:30])[CH2:1][CH2:2][CH2:3][CH3:4])[N:9]=1)[C:23]([O:25][CH3:26])=[O:24])=[O:17])=[N+:32]=[N-:33]