Hydrochloric Acid → HCID 71062250, compound

Participants

Reaction Steps

To a solution of methyl 4-(6-(dibutylcarbamoyl)pyridin-2-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (158 mg, 0.30 mmol) in THF (2.0 mL) and MeOH (2.0 mL) was added 2N NaOH (1.5 mL, 3.00 mmol). The resulting reaction mixture was stirred at room temperature for 2 h. At 0° C., the reaction mixture was neutralized to pH 4-5 with 1N HCl. The solution was extracted with EtOAc (3×) and the combined organic extracts were dried over MgSO4, filtered and concentrated in vacuo to afford the title compound (146 mg, 95%). MS(ESI+) m/z 514.4 (M+H)+.

Provenance & Evidence