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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 529049Generated: October 29, 2026

Hydrochloric Acid → HCID 86708889, compound

https://huagongshe.com/reaction/529049

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantTrifluoroacetic acidHCID 6422—
ReactantPotassium HydroxideHCID 14797—
ReactantHCID 86708891HCID 86708891—
SolventMethanolHCID 887—
ProductHCID 86708889HCID 86708889—

Reaction Steps

To a solution of methyl 1-(1-methyl-1H-pyrazol-4-yl)-1H-indole-3-carboxylate, TFA (3.5 mg, 9.48 μmol) in MeOH (95 μl) was added a solution of aq. KOH (33.2 μl, 0.066 mmol, 2 M). The reaction mixture was stirred at RT overnight, then acidified with 1N HCl. The solvent was evaporated under reduced pressure and the residue was dried under vacuum overnight. The title compound was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09346829B2
Source datasetuspto-grants-2016_05
ORD IDord-41462f9bc752468089905cf0c231d464
Source noteuspto-grants-2016_05