Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 86651805, compound

HRID 529100Notes

Reaction equation

HRID 529100 reaction equation
[C:1]([O:5][C:6]([N:8]1[C@H:12]([C:13]([OH:15])=O)[CH2:11][C@:10]2([C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][C:16]2=[O:24])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:26][NH:27][O:28][CH3:29]>>[CH3:29][O:28][N:27]([CH3:26])[C:13]([C@H:12]1[N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[CH2:9][C@@:10]2([C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[NH:17][C:16]2=[O:24])[CH2:11]1)=[O:15]

Participants

3

Reactant 2

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 69810850HCID 69810850, compound

Product 1

HCID 86651805HCID 86651805, compound

Procedure

(3S,5′S)-tert-butyl 5′-(methoxy(methyl)carbamoyl)-2-oxospiro[indoline-3,3′-pyrrolidine]-1′-carboxylate was prepared by the procedures described in Example 10, Step 5, substituting (R)-2-(1′-(tert-butoxycarbonyl)-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4′-piperidine]-5-yl)acetic acid with (3S,5′ S)-1′-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxylic acid, and substituting NH4Cl with N,O-dimethylhydroxylamine hydrochloride. LCMS (APCI+) m/z 376 [M+H]+; Rt=2.88 min.

Sources & evidence

ORD record
ord-86a1bc65897141989958508188e2a6bc
Source dataset
uspto-grants-2016_05
Patent number
US09346805B2

Reaction notes

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