HCID 69812225, compound → HCID 44197605, compound

Participants

Reaction Steps

(S)—N-((1-(5-Cyclopentyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4′-piperidine]-4-yl)methyl)propan-2-amine was prepared as described in Example 80, substituting cyclopentylmagnesium bromide for ethylmagnesium bromide in Step 1. 1H NMR (CDCl3, 400 MHz) δ 8.62 (s, 1H), 7.08-7.26 (m, 2H), 6.97 (d, 1H), 4.01 (s, 2H), 3.88-3.97 (m, 2H), 3.42 (m, 1H), 3.14 (dd, 2H), 2.96-2.98 (m, 3H), 2.80 (dt, 2H), 2.57-2.59 (m, 1H), 2.09-2.21 (m, 3H), 1.93 (m, 1H), 1.86 (m, 2H), 1.59 (d, 1H), 1.34-1.48 (m, 6H), 1.11 (s, 6H), 0.99 (m, 1H). (S)—N-((1-(5-cyclopentyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4′-piperidine]-4-yl)methyl)propan-2-amine trihydrochloride. MS (APCI+) [M+H]: 446.3.

Provenance & Evidence