HCID 53386758, compound → HCID 59000861, compound

HRID 529173Notes

Reaction equation

HRID 529173 reaction equation
[F:1][C:2]1[CH:41]=[CH:40][CH:39]=[C:38]([F:42])[C:3]=1[CH2:4][N:5]1[C:10]2[S:11][C:12]([C:21]3[CH:26]=[CH:25][C:24]([NH:27][C:28]([NH:30][O:31][CH3:32])=[O:29])=[CH:23][CH:22]=3)=[C:13]([CH2:14][N:15]([CH2:17][CH2:18][O:19][CH3:20])[CH3:16])[C:9]=2[C:8](=[O:33])[N:7]([CH2:34][CH2:35]O)[C:6]1=[O:37].[NH:43]1[CH:47]=[N:46][N:45]=[N:44]1>>[F:42][C:38]1[CH:39]=[CH:40][CH:41]=[C:2]([F:1])[C:3]=1[CH2:4][N:5]1[C:10]2[S:11][C:12]([C:21]3[CH:26]=[CH:25][C:24]([NH:27][C:28]([NH:30][O:31][CH3:32])=[O:29])=[CH:23][CH:22]=3)=[C:13]([CH2:14][N:15]([CH2:17][CH2:18][O:19][CH3:20])[CH3:16])[C:9]=2[C:8](=[O:33])[N:7]([CH2:34][CH2:35][N:43]2[CH:47]=[N:46][N:45]=[N:44]2)[C:6]1=[O:37]

Participants

3

Reactant 2

HCID 53386758HCID 53386758, compoundHCID 178418441HCID 178418441, compound

Product 1

HCID 59000861HCID 59000861, compound

Procedure

The similar reaction as described in Example 6 by using the compound obtained in Example 8 (250 mg, 0.414 mmol) and tetrazole (145 mg, 2.07 mmol) gave the title compound 2-yl form (66 mg, 24%) and 1-yl form (27 mg, 10%) as white amorphous compounds.

Workup

  1. customThe similar reaction

Sources & evidence

ORD record
ord-bb36fff04d854fc6942b2dc9e639e39e
Source dataset
uspto-grants-2016_05
Patent number
US09346822B2

Reaction notes

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