Trifluoroacetic acid → HCID 118194610, compound

Participants

Reaction Steps

To tert-butyl(1-(cyclopropylamino)-2,2-dimethoxy-1-oxohexan-3-yl)carbamate (prepared from product of Example 19 by saponification and amidation using the conditions described in example 22 and 23) (25 mg, 0.075 mmol) in DCM (1 mL) was added a catalytic amount of TFA and the mixture was stirred for 1 h. The acid was neutralized with solid NaHCO3 and precipitates were filtered off. The solvent was removed under reduced pressure to give 20 mg of the amine.

Provenance & Evidence