Trifluoroacetic acid → HCID 90244054, compound

Participants

Reaction Steps

TFA (2.45 mL, 32.1 mmol) was added to a solution of (S)-tert-butyl 1-(cyclopropylamino)-2,2-diethoxy-1-oxohexan-3-ylcarbamate (2.3 g, 6.41 mmol) in 45 mL CH2Cl2 and the mixture was stirred at room temperature for 18 hours. A saturated NaHCO3 solution was carefully added to the mixture, the aqueous phase was extracted with CH2Cl2 (2×30 mL) and the combined organic phases were dried over Na2SO4. Removal of the solvent in vacuo yielded 1.44 g (3S)-3-Amino-N-cyclopropyl-2,2-diethoxyhexanamide as a pale yellow oil.

Provenance & Evidence