HRID52939

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCCCc1nc(C(O)(C(C)C)C(C)C)c(C#N)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1

HCID19036147

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nc(C(O)(C(C)C)C(C)C)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1

HCID19036078

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

10 ml of a 1N aqueous solution of sodium hydroxide were added to a solution of 500 mg of 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-[1-hydroxy-2-methyl-1-(1-methylethyl)propyl]imidazole-5-carbonitrile [prepared as described in step (a) above] in 10 ml of ethanol, and the resulting mixture was heated under reflux for 20 hours. At the end of this time, the reaction mixture was worked up in a similar manner to that described in Example 45(c), to give 220 mg of the title compound as an amorphous solid.

WORKUP

后处理

temperaturethe resulting mixture was heated
temperatureunder reflux for 20 hours

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d8d4e3d6c68b4d9d8fa6dc6611d80647
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05616599
来源说明: uspto-grants-1997_04

反应 SMILES

[OH-:1].[Na+].[C:3]([O:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[C:27]([C:28]#[N:29])=[C:26]([C:30]([OH:37])([CH:34]([CH3:36])[CH3:35])[CH:31]([CH3:33])[CH3:32])[N:25]=[C:24]2[CH2:38][CH2:39][CH2:40][CH3:41])=[CH:18][CH:17]=1)=[O:9])([CH3:6])([CH3:5])[CH3:4]>C(O)C>[C:3]([O:7][C:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[C:27]([C:28]([NH2:29])=[O:1])=[C:26]([C:30]([OH:37])([CH:31]([CH3:33])[CH3:32])[CH:34]([CH3:35])[CH3:36])[N:25]=[C:24]2[CH2:38][CH2:39][CH2:40][CH3:41])=[CH:18][CH:17]=1)=[O:9])([CH3:4])([CH3:5])[CH3:6]