Potassium Phosphate, Tribasic → HCID 86709315, compound

Participants

Reaction Conditions

Reaction Steps

A vial was charged with (E)-7-bromo-3-chloro-6′,7′-dihydro-2′H-spiro[chromeno[2,3-c]pyridine-5,3′-[1,4]oxazepin]-5′-amine (280.9 mg, 0.712 mmol), 2-fluoropyridin-3-ylboronic acid (150 mg, 1.068 mmol), Pd(AmPhos)2Cl2 (25.2 mg, 0.036 mmol), and potassium phosphate (453 mg, 2.135 mmol). The vial was flushed with Ar (g), then 1,4-dioxane (2669 μL) and water (890 μL) were added in sequence. The vial was sealed and heated in a microwave reactor for 20 min at 90° C. The mixture was extracted with EtOAc (3×), and the combined organic extracts were concentrated. The crude product was purified by chromatography on silica gel (0-10% MeOH/DCM) to give (E)-3-chloro-7-(2-fluoropyridin-3-yl)-6′,7′-dihydro-2′H-spiro[chromeno[2,3-c]pyridine-5,3′-[1,4]oxazepin]-5′-amine as a white solid.

Provenance & Evidence