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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 52944Generated: October 25, 2026

Glycine ethyl ester, hydrochloride → N-Ethoxycarbonylmethyl-2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-hydroxymethylimidazole-5-carboxamide

https://huagongshe.com/reaction/52944

Reaction equation

Participants

RoleNameHCIDCharge
ReactantGlycine ethyl ester, hydrochlorideHCID 2723640—
ReactantSuccinimido 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-hydroxymethylimidazole-5-carboxylateHCID 19036239—
SolventTriethylamineHCID 8471—
ProductN-Ethoxycarbonylmethyl-2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-hydroxymethylimidazole-5-carboxamideHCID 19036286—

Reaction Steps

Following a procedure similar to that described in Example 53, but using 0.307 g of succinimido 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-hydroxymethylimidazole-5-carboxylate [prepared as described in Example 52(a)], 89 mg of ethyl glycinate hydrochloride and 0.089 ml of triethylamine, 0.202 g of the

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05616599
Source datasetuspto-grants-1997_04
ORD IDord-d8ae651d28ae461294e4f692d26523fc
Source noteuspto-grants-1997_04