HCID 68292675, compound → HCID 68291938, compound

Participants

Reaction Steps

To a round bottom flask was added a solution of (2S,3E,5S)-2-benzyl-1,6-bis((7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzothiazol-1(3H,4H)-yl)-5-(2-methylprop-2-en-1-yl)hex-3-ene-1,6-dione (67 mg, 0.098 mmol) in AcOH (10.5 mL) and 10% Pd/C (12 mg, 0.011 mmol). The reaction was stirred under an atmosphere of hydrogen (balloon) for 2 hr. The reaction mixture was diluted with EtOAc and filtered. The catalyst was rinsed with EtOAc and the filtrate was concentrated to give (2S,3E,5S)-2-benzyl-1,6-bis((7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzothiazol-1(3H,4H)-yl)-5-(2-methylpropyl)hex-3-ene-1,6-dione (54 mg, 0.079 mmol, 80% yield) as a syrup. Anal. Calcd. for C32H52N2O6S2 m/z 684.2. found: 685.2 (M+H)+.

Provenance & Evidence