Hydrogen Bromide → HCID 68292665, compound

Participants

Reaction Conditions

Reaction Steps

To a round bottom flask was added (2R,5R)-2-benzyl-5-(4-methoxybenzyl)hexanedioic acid (30 mg, 0.084 mmol) and 30% HBr in acetic acid (0.5 mL). The reaction was stirred at 120° C. for 16 h. Then the solvent was removed. The residue was purified by RP prep-HPLC (Method A). The fraction was concentrated to give (2R,5R)-2-benzyl-5-(4-hydroxybenzyl)hexanedioic acid (10 mg, 0.029 mmol, 35% yield) as an off-white solid.

Provenance & Evidence