Pyridinium chloride → HCID 68292072, compound

Participants

Reaction Conditions

Reaction Steps

To a round bottom flask was added (2R,5R)-2,5-bis(4-methoxybenzyl)hexanedioic acid (124 mg, 0.321 mmol) and pyridine hydrochloride (371 mg, 3.21 mmol). The reaction was stirred at 160° C. for 20 min. After cooling to rt, the reaction was diluted with water and extracted with EtOAc (2×15 mL). The combined EtOAc extracts were concentrated in vacuum. The resulting residue was purified using RP prep-HPLC (Method B) to give (2R,5R)-2-(4-hydroxybenzyl)-5-(4-methoxybenzyl)hexanedioic acid (37 mg, 0.099 mmol, 31% yield) as white solid.

Provenance & Evidence