Piperidine → HCID 68292599, compound

Participants

Reaction Steps

To a round bottom flask was added (9H-fluoren-9-yl)methyl (3R)-2,2-dimethyl-4-oxooctahydropyrido[2,1-b][1,3]thiazin-3-ylcarbamate (37 mg, 0.085 mmol), DCM (1 mL) and piperidine (0.017 mL, 0.17 mmol). The reaction was stirred at rt for 3 hr. The solvent was removed and the residue was dried over vacuum pump overnight to give (3R)-3-amino-2,2-dimethylhexahydropyrido[2,1-b][1,3]thiazin-4(6H)-one (17 mg, 0.080 mmol, 94% yield).

Provenance & Evidence