P-Anisidine → HCID 178472672, compound

Participants

Reaction Steps

To a round bottom flask was added 4-methoxyaniline (10 g, 81 mmol), toluene (100 mL) and Na2SO4 (40 gm). Then a solution of ethyl 2-oxoacetate (8.29 gm, 81 mmol) in toluene (20 mL) was slowly added to the reaction over 45 min. The reaction was stirred at rt for an additional 30 min. Then, the Na2SO4 was filtered off and the filtrate was concentrated to give (Z)-ethyl 2-(4-methoxyphenylimino)acetate (5.0 g, 24 mmol, 30% yield) as a clear oil.

Provenance & Evidence