Hydrochloric Acid → (Z)-3-amino-4,4-dimethyl-1-phenyl-3,4-dihydro-1H-azepin-2(7H)-one

Participants

Reaction Steps

To a round bottom flask was added (Z)-tert-butyl 4,4-dimethyl-2-oxo-1-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-ylcarbamate (7 mg, 0.02 mmol) and 4 N HCl in dioxane (1 mL). The reaction was stirred at rt for 1 hr. The solvent was removed to give (Z)-3-amino-4,4-dimethyl-1-phenyl-3,4-dihydro-1H-azepin-2(7H)-one (4 mg, 0.02 mmol, 82% yield) as mono hydrochloride salt. Anal. Calcd. for C14H18N2O m/z 230.2. found: 231.2 (M+H)+.

Provenance & Evidence