4-Methylmorpholine → tert-butyl (4S,7S,10aS)-7-(hydrazinecarbonyl)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate

Participants

Reaction Conditions

Reaction Steps

To a solution of (4S,7S,10aS)-4-(tert-butoxycarbonylamino)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid (121 mg, 0.351 mmol) and N-methylmorpholine (0.048 mL, 0.44 mmol) in DCM (2 mL) at 0° C. was added isobutyl carbonochloridate (0.053 mL, 0.40 mmol). The mixture was stirred at 0° C. for 40 min. Then, hydrazine (0.044 mL, 1.4 mmol) was added and the reaction was stirred at rt for 1 hr. The mixture was diluted with EtOAc and washed with water and saturated aqueous NaCl. The organic layer was separated, dried over MgSO4, filtered and concentrated to give tert-butyl (4S,7S,10aS)-7-(hydrazinecarbonyl)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate (125 mg, 0.349 mmol, 99% yield) as a white solid. Anal. Calcd. for C15H26N4O4S m/z 358.4. found: 359.1 (M+H)+.

Provenance & Evidence