Hydrochloric Acid → (4S,7S,10aS)-4-Amino-5-oxo-N-propyloctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxamide hydrochloride salt

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Reaction Steps

To a round bottom flask was added tert-butyl (4S,7S,10aS)-5-oxo-7-(propylcarbamoyl)octahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate (43 mg, 0.11 mmol) and 4 M HCl in dioxane (1 mL). The mixture was stirred at rt for 1 hr. The reaction mixture was concentrated to give (4S,7S,10aS)-4-Amino-5-oxo-N-propyloctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxamide hydrochloride salt (36 mg, 0.11 mmol, 100% yield).

Provenance & Evidence