tert-Butyl bromoacetate → HCID 68292159, compound

HRID 529512Notes

Reaction equation

HRID 529512 reaction equation
[CH2:1]([C@@H:8]([CH2:12][CH2:13][C@H:14](CCC(OC(C)(C)C)=O)[C:15]([OH:17])=[O:16])[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>>[CH2:1]([C@@H:8]([CH2:12][CH2:13][C@H:14]([CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[C:15]([OH:17])=[O:16])[C:9]([OH:11])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 68292426HCID 68292426, compound

Product 1

HCID 68292159HCID 68292159, compound

Procedure

(2R,5R)-2-Benzyl-5-(2-tert-butoxy-2-oxoethyl)hexanedioic acid (33 mg, 0.094 mmol) was synthesized as described for the preparation of Intermediate 7 using tert-butyl bromoacetate in step A.

Sources & evidence

ORD record
ord-d167ad4e32ff46ed987d463673810fc9
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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