(R)-Tert-butyl 2-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate → tert-butyl (2R)-2-formylpiperidine-1-carboxylate

Participants

Reaction Steps

LiAlH4 (110 mg, 2.89 mmol) was added in portions to a 0° C. solution of (R)-tert-butyl 2-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (525 mg, 1.93 mmol) in ether (9 mL). The reaction mixture was then stirred at rt for 30 min. The reaction mixture was cooled to 0° C. and carefully quenched by dropwise addition of aqueous 5% KHSO4 (10 mL). The mixture was then extracted with ether (2×15 mL). The organic extracts were combined, washed with 10% aqueous citric acid, 5% aqueous NaHCO3 and saturated aqueous NaCl. The ether was then dried over MgSO4, filtered and concentrated to give (R)-tert-butyl 2-formylpiperidine-1-carboxylate (392 mg, 1.84 mmol, 95% yield) of a colorless oil. 1H NMR (400 MHz, CDCl3) δ ppm 9.59 (1H, s), 4.71-4.44 (1H, m), 4.12-3.79 (1H, m), 3.05-2.78 (1H, m), 2.17 (1H, d, J=11.5 Hz), 1.73-1.55 (4H, m), 1.46 (9H, s), 1.34-1.18 (1H, m).

Provenance & Evidence