HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-(((tert-butoxy)carbonyl)amino)hex-5-enoic acid → (7S,11aR,Z)-7-Amino-3,4,7,8,9,11a-hexahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-(((tert-butoxy)carbonyl)amino)hex-5-enoic acid | HCID 20765220 | — |
| Reactant | (7S,10aR,Z)-7-amino-1,2,3,4,7,8-hexahydropyrido[1,2-a]azepin-6(10aH)-one hydrochloride | HCID 68292606 | — |
| Product | (7S,11aR,Z)-7-Amino-3,4,7,8,9,11a-hexahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrochloride | HCID 86706217 | — |
Reaction Steps
(7S,11aR,Z)-7-Amino-3,4,7,8,9,11a-hexahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrochloride (538 mg, 2.332 mmol) was synthesized as described for the preparation of Intermediate 53 using (S)-2-(tert-butoxycarbonylamino)hex-5-enoic acid in step E. Anal. Calcd. for C11H18N2O m/z 194.2. found: 195.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346852B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-5e7cbe107ade49d0a24aea0f3c227bca |
| Source note | uspto-grants-2016_05 |