N-allyl-3-methoxyaniline → (S)-3-Amino-1-(3-methoxyphenyl)azepan-2-one trifluoroacetate

HRID 529537Notes

Reaction equation

HRID 529537 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:8][C@H:9]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2OC)[C:10]1=[O:24].C(NC1C=CC=[C:31]([O:35]C)C=1)C=C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:8][C@H:9]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([C:16]2[CH:17]=[CH:18][CH:19]=[C:20]([O:35][CH3:31])[CH:21]=2)[C:10]1=[O:24]

Participants

3

Reactant 2

HCID 14069075N-allyl-3-methoxyanilineHCID 68292209(S)-3-amino-1-(2-methoxyphenyl)azepan-2-one trifluoroacetate

Product 1

HCID 68292672(S)-3-Amino-1-(3-methoxyphenyl)azepan-2-one trifluoroacetate

Procedure

(S)-3-Amino-1-(3-methoxyphenyl)azepan-2-one trifluoroacetate (143 mg, 0.411 mmol) was synthesized as described for the preparation of Intermediate 62 using N-allyl-3-methoxyaniline in step A.

Sources & evidence

ORD record
ord-0e766522907e41ac87e72b509cae2fe0
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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