Hydrochloric Acid → 1-[(2'-Carboxybiphenyl-4-yl)methyl]-4-(1-hydroxy-2,2-dimethylpropyl)-2-propylimidazole-5-carboxamide

Participants

Reaction Steps

Following a procedure similar to that described in Example 52(c), but using 139 mg of 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-2,2-dimethylpropyl)-2-propylimidazole-5-carboxamide [prepared as described in step (g) above], 96 mg of the hydrochloride of the title compound were obtained as a powder, melting at above 160° C. (with softening).

Provenance & Evidence