(S)-3-amino-1-o-tolylazepan-2-one → (2R,5R)-2,5-Dibenzyl-6-oxo-6-((S)-2-oxo-1-o-tolylazepan-3-ylamino)hexanoic acid

Participants

Reaction Steps

(2R,5R)-2,5-Dibenzyl-6-oxo-6-((S)-2-oxo-1-o-tolylazepan-3-ylamino)hexanoic acid (65 mg, 0.12 mmol) was synthesized as described for the preparation of Intermediate 70 using (S)-3-amino-1-o-tolylazepan-2-one. Anal. Calcd. for C33H38N2O4 m/z 526.4. found: 527.4 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.37-6.84 (m, 16H), 4.84-4.72 (m, 1H), 4.01-3.78 (m, 1H), 3.51 and 3.28 (dd, J=15.0, 4.8 Hz, 1H), 3.04-2.81 (m, 2H), 2.79-2.61 (m, 3H), 2.50-2.37 (m, 1H), 2.18 (s, 1H), 2.13 (s, 2H), 2.03-1.44 (m, 10H).

Provenance & Evidence