tert-butyl (4S,7S,10aS)-5-oxo-7-vinyloctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate → tert-butyl (4S,7R,10aS)-7-ethyl-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate

Participants

Reaction Steps

A solution of tert-butyl (4S,7S,10aS)-5-oxo-7-vinyloctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate (66 mg, 0.20 mmol) in MeOH (2 mL) was purged with argon for 2 min. Then, 10% Pd/C (80 mg, 0.75 mmol) was added. The reaction mixture was stirred for under a hydrogen balloon for 3 days. The reaction mixture was filtered. The filtrate was concentrated and dried under the high vacuum to give tert-butyl (4S,7R,10 aS)-7-ethyl-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate (52 mg, 0.16 mmol, 78% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 6.02 (d, J=5.5 Hz, 1H), 5.39-5.15 (m, 1H), 4.92-4.66 (m, 1H), 4.53-4.30 (m, 1H), 3.38-3.14 (m, 1H), 2.97-2.66 (m, 1H), 2.46-2.20 (m, 1H), 2.15-1.62 (m, 8H), 1.62-1.35 (m, 10H), 0.93 (t, J=7.4 Hz, 3H).

Provenance & Evidence