HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Pivaloyloxymethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole | HCID 10053461 | — |
| Reactant | HCID 178440080 | HCID 178440080 | — |
| Product | Pivaloyloxymethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate | HCID 19036272 | 48.8% |
Reaction Steps
Following a procedure similar to that described in Example 61(a), but using 0.85 g of pivaloyloxymethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate [prepared as described in Preparation 22(ii)], 1.52 g of 4-[2-(trityltetrazol-5-yl)phenyl]benzyl bromide and 0.72 g of potassium carbonate, 1.02 g of the title compound were obtained as an amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616599 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-9a4066bbe032494192d616df6052fd4f |
| Source note | uspto-grants-1997_04 |